RCTs might not meet the real world in cluster headache daily clinical practice
Paolo Martelletti and Martina Curto
Recently published American Headache Society evidence-based guidelines for cluster headache management provide updated guidance on which therapies are superior to placebo in randomized controlled trials. These valuable recommendations do not always translate to real-world settings, however, and other criteria should be taken into account when attempting to treat cluster headache.
Refers to Robbins M.S. Et al. Treatment of cluster headache: the American Headache Society evidence-based guidelines. Headache 56, 1093-1106 (2016).